Efficacy and safety of herbal medicine on dementia and cognitive function: An umbrella review of systematic reviews and meta‐analysis

Author:

Sawangjit Ratree12ORCID,Chuenchom Chorthip1,Sanverm Thanchanok1,Chaiyakunapruk Nathorn3,Jiranukool Jariya4,Nithipaijit Rodchares12,Sadoyu Saranrat5,Phianchana Chankiat1,Jinatongthai Peerawat6

Affiliation:

1. Department of Clinical Pharmacy, Faculty of Pharmacy Mahasarakham University Mahasarakham Thailand

2. Clinical Trials and Evidence‐Based Syntheses Research Unit (CTEBs RU) Mahasarakham University Mahasarakham Thailand

3. Department of Pharmacotherapy College of Pharmacy, University of Utah Salt Lake City Utah USA

4. Department of Psychiatry, Faculty of Medicine Mahasarakham University Mahasarakham Thailand

5. Pakchongnana Hospital Nakhon Ratchasima Thailand

6. Pharmacy Practice Division, Faculty of Pharmaceutical Sciences Ubon Ratchathani University Ubon Ratchathani Thailand

Abstract

AbstractThis study aims to summarize the effects of herbs on dementia and assess the strength of evidence. Six international and local databases were searched from inception to October 2021 for systematic reviews and meta‐analyses of clinical trials investigated the effects of herbal medicine on dementia or cognitive function. Two researchers independently extracted data, assessed the methodological quality, and rated the credibility of evidence according to established criteria. Thirty‐seven articles evaluating 13 herbal medicines were included. Of these, 65% were rated critically low using AMSTAR2. Of 90 unique outcomes, 41 (45.6%) were statistically significant based on random effects model (p ≤ .05). Only 3 herbs were supported by suggestive evidence whereas the others were supported by weak evidence. The suggestive evidence supported benefits of Chinese herbal medicine (CHM) plus pharmacotherapy (WMD:1.84; 95% CI: 1.34, 2.35) and Vinpocetine (WMD: −0.94; 95%CI: −1.50, −0.38) on improving cognitive function assessing by Montreal Cognitive Assessment and Syndrom‐Kurz‐Test, respectively. Moreover, suggestive evidence supported benefit of Huperzia serrata on improving Activities of Daily Living (WMD:‐7.18; 95%CI: −9.12, −5.23). No SAE was reported. In conclusion, several herbs were used for improving dementia and cognitive function but recent evidence were limited by the small sample size and poor methodological quality. Therefore, further large and well‐designed studies are needed to support the evidence.

Funder

Mahasarakham University

Publisher

Wiley

Subject

Pharmacology

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