The ChaC1 active site: Defining the residues and determining the role of ChaC1 ‐exclusive residues in the structural and functional stability
Author:
Affiliation:
1. Department of Biological Sciences Indian Institute of Science Education and Research Mohali Punjab India
2. Department of Experimental Medicine and Biotechnology Postgraduate Institute of Medical Education and Research Chandigarh India
Funder
Department of Science and Technology, Ministry of Science and Technology, India
Publisher
Wiley
Subject
Molecular Biology,Biochemistry,Structural Biology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/prot.26450
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1. Mammalian proapoptotic factor ChaC1 and its homologues function as γ‐glutamyl cyclotransferases acting specifically on glutathione
2. CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade
3. Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program
4. CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway
5. Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients
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