Simultaneous quantification of seven glycols in antifreeze liquids using direct liquid injection gas chromatography coupled with mass spectrometry

Author:

Danila George Madalin1ORCID,Cretu Mihaiella2,Puscasu Cristian2

Affiliation:

1. Cromatec Plus SRL, Research Center for Instrumental Analysis SCIENT Tancabesti Ilfov Romania

2. National Research and Development Institute of Gas Turbines COMOTI Bucharest Romania

Abstract

Glycol‐based antifreeze liquids, commonly composed of ethylene glycol or propylene glycol, have important uses in automotive cooling, but they should be handled with care due to their toxicity. Ethylene glycol is highly toxic to humans and animals. A fast, accurate, precise, and robust method was developed for the simultaneous quantification of seven most important glycols and their isomers.MethodsGlycols were analyzed from diluted sample solution of coolants using gas chromatography coupled with mass spectrometry (GC–MC) in single ion monitoring mode.ResultsThe method was developed and validated for seven individual glycols (ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, and tripropylene glycol). Limits of detection (1–2 μg/mL) and limits of quantification (10 μg/mL) obtained were appropriate. The present method was applied for the determination of glycols in 10 different antifreeze liquids commercially available on the Romanian market, proving to be reliable.ConclusionsA method that requires only a two‐step dilution of antifreeze samples combined with direct liquid injection GC–MS was validated for the simultaneous quantification of seven glycols (and their isomers) in 10 different types of antifreeze liquids. The results obtained in the validation procedure proved that the GC–MS method is sensitive and precise for the quantification of glycols.

Funder

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference7 articles.

1. Ethylene glycol poisoning may be associated with elevated post-mortem vitreous glucose level

2. GiesenY FriedrichC BreuerD et al.Glycols—method for the determination of diethylene glycol ethylene glycol and propylene glycol in workplace air using gas chromatography [air monitoring methods 2018]. The MAK‐Collection for Occupational Health and Safety.

3. Determination of Glycols in Biological Specimens by Gas Chromatography-Mass Spectrometry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3