Classification and Clinical Management of Variants of Uncertain Significance in High Penetrance Cancer Predisposition Genes-Reference-Cited by-同舟云学术

Classification and Clinical Management of Variants of Uncertain Significance in High Penetrance Cancer Predisposition Genes

Published:2016-02-05 Issue:4 Volume:37 Page:331-336
ISSN:1059-7794
Container-title:Human Mutation
language:en
Short-container-title:Human Mutation

Author:

Moghadasi Setareh¹,Eccles Diana M.²,Devilee Peter³,Vreeswijk Maaike P.G.³,van Asperen Christi J.¹

Affiliation:

1. Department of Clinical Genetics; Leiden University Medical Centre; Leiden 2333 ZA The Netherlands

2. Faculty of Medicine, University of Southampton, Wessex Clinical Genetics Service; Princess Anne Hospital; Southampton SO16 5YA United Kingdom

3. Department of Human Genetics; Leiden University Medical Centre; Leiden 2333 ZC The Netherlands

Funder

Netherlands Organization for Scientific Research (NWO), research program Mosaic

Van de Kampfonds from Leiden University Medical Centre

Publisher

Wiley

Subject

Genetics(clinical),Genetics

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/humu.22956/fullpdf

Reference40 articles.

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3. A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes;Easton;Am J Hum Genet,2007

4. Understanding of BRCA VUS genetic results by breast cancer specialists;Eccles;BMC Cancer,2015a

5. BRCA1 and BRCA2 genetic testing-pitfalls and recommendations for managing variants of uncertain clinical significance;Eccles;Ann Oncol,2015b

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