Dose Rationalization of Pembrolizumab and Nivolumab Using Pharmacokinetic Modeling and Simulation and Cost Analysis

Author:

Ogungbenro Kayode1,Patel Alkesh2,Duncombe Robert2,Nuttall Richard3,Clark James2,Lorigan Paul24

Affiliation:

1. Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and HealthUniversity of Manchester, Manchester Academic Health Science CentreManchester United Kingdom

2. The Christie NHS Foundation TrustManchester United Kingdom

3. The Royal Marsden NHS Foundation TrustLondon United Kingdom

4. Institute of Molecular and Clinical Cancer SciencesUniversity of Manchester

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference34 articles.

1. The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma

2. Pembrolizumab

3. Pembrolizumab: First Global Approval

4. KEYTRUDA (pembrolizumab) [package inserts]. Merck & Co. (2016). Accessed 27 January2016.

5. OPDIVO (nivolumab) [package inserts] Bristol‐Myers Squibb. (2016). Accessed 13 February 2017.

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