A novel real-time method to estimate volumetric mass biodensity based on the combination of dielectric spectroscopy and soft-sensors

Author:

Ehgartner Daniela1,Sagmeister Patrick2,Herwig Christoph21,Wechselberger Patrick1

Affiliation:

1. CD Laboratory on Mechanistic and Physiological Methods for Improved Bioprocesses; Vienna University of Technology; Austria

2. Institute of Biochemical Engineering; Vienna University of Technology; Austria

Publisher

Wiley

Subject

Inorganic Chemistry,Organic Chemistry,Pollution,Waste Management and Disposal,Fuel Technology,Renewable Energy, Sustainability and the Environment,General Chemical Engineering,Biotechnology

Reference60 articles.

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2. www.ich.org

3. CMC Biotech Working Group http://www.casss.org/associations/9165/files/A-Mab_Case_Study_Version_2-1.pdf

4. PAT method to gather bioprocess parameters in real-time using simple input variables and first principle relationships;Wechselberger;Chem Eng Sci,2010

5. Quality by design case study: an integrated multivariate approach to drug product and process development;Huang;Int J Pharmaceut,2009

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