Fermentanomics informed amino acid supplementation of an antibody producing mammalian cell culture
Author:
Affiliation:
1. Div. of Monoclonal Antibodies; CDER, FDA; Silver Spring MD
2. Small Molecule Design and Development; Eli Lilly and Company; Indianapolis IN
3. Div. of Product Quality Research; CDER, FDA; Silver Spring MD
Publisher
Wiley
Subject
Biotechnology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/btpr.1728/fullpdf
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3. Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism;Jeong;Mol Cell Biochem.,2006
4. High-level expression of full-length antibodies using trans-complementing expression vectors;Bianchi;Biotechnol Bioeng.,2003
5. Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange;Wong;Nucleic Acids Res.,2005
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