Long-term weight change after oesophageal cancer surgery

Author:

Martin L1,Lagergren P1

Affiliation:

1. Unit of Oesophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Abstract

Abstract Background Malnutrition is common after oesophageal cancer surgery. This study investigated weight changes and the risk of malnutrition among long-term survivors. Methods A nationwide cohort study was conducted in Sweden in 2001–2004, with follow-up to 2008. Weight was assessed before oesophagectomy, after 6 months and at 3 years. Logistic regression was performed with adjustment for confounders. Odds ratios (ORs) for postoperative weight loss of at least 15 per cent were estimated. Results Some 203 patients survived at least 3 years after oesophagectomy. Continuous weight loss occurred for up to 3 years. Women and men had a similar risk of malnutrition after 3 years (OR 0·85 (95 per cent confidence interval 0·24 to 2·98)). In overweight patients (preoperative body mass index at least 25 kg/m2) the risk of malnutrition was increased almost fivefold at 6 months (OR 4·90 (2·27 to 10·59)) and 3 years (OR 4·60 (1·80 to 11·78)). There was no difference in weight loss at 6 months between survivors and those who died between 6 months and 3 years after surgery (OR 1·11 (0·64 to 1·94)). Conclusion Weight loss can be long lasting after oesophagectomy; overweight patients are at particularly increased risk of malnutrition.

Publisher

Oxford University Press (OUP)

Subject

Surgery

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