No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury-Reference-Cited by-同舟云学术

No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury

Published:2023-01-24 Issue:3 Volume:10 Page:453-458
ISSN:2328-9503
Container-title:Annals of Clinical and Translational Neurology
language:en
Short-container-title:Ann Clin Transl Neurol

Author:

Sachdeva Rahul¹^ORCID,Hosseinzadeh Ali¹,Rizzardo Aaron²,Maharaj Andrea¹,Berger Michael¹³,Krassioukov Andrei¹³⁴^ORCID

Affiliation:

1. International Collaboration on Repair Discoveries University of British Columbia British Columbia Vancouver Canada

2. Department of Medicine, Division of Community Internal Medicine University of British Columbia British Columbia Vancouver Canada

3. Department of Medicine, Division of Physical Medicine and Rehabilitation University of British Columbia British Columbia Vancouver Canada

4. Spinal Cord Program, GF Strong Rehabilitation Centre University of British Columbia British Columbia Vancouver Canada

Abstract

AbstractBackgroundOpioids effectively reduce chronic pain, but present significant side effects including opioid‐induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population remains understudied.MethodsWe assessed whether oxycodone/naloxone reduces pain, constipation, and severity of autonomic dysreflexia in an individual with spinal cord injury. A 55‐year‐old male with C5 lesion presented with chief complaint of chronic pain received 5/2.5 mg and 20/10 mg oxycodone/naloxone for 6 and 2 weeks, respectively.ResultsOxycodone/naloxone improved pain, bowel function, and autonomic dysreflexia severity.InterpretationOxycodone/naloxone was effective in managing chronic pain and constipation in the studied case.

Publisher

Wiley

Subject

Neurology (clinical),General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/acn3.51734

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