A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization

Author:

Bowden Jack1,Del Greco M Fabiola2,Minelli Cosetta3,Davey Smith George1,Sheehan Nuala4,Thompson John4

Affiliation:

1. MRC Integrative Epidemiology Unit; University of Bristol; U.K.

2. Center for Biomedicine; EURAC research; Bolzano Italy

3. Population Health and Occupational Disease; NHLI, Imperial College; London U.K.

4. Department of Health Sciences; University of Leicester; Leicester U.K.

Funder

MRC Methodology Research Fellowship

MRC Integrative Epidemiology Unit at the University of Bristol

Publisher

Wiley

Subject

Statistics and Probability,Epidemiology

Reference35 articles.

1. Mendelian randomization: can genetic epidemiology contribute to understanding environmental determinants of disease;Davey Smith;International Journal of Epidemiology,2003

2. Mendelian randomization: genetic anchors for causal inference in epidemiological studies;Davey Smith;Human Molecular Genetics,2014

3. Large-scale association analysis identifies new risk loci for coronary artery disease;CARDIoGRAMplusC4D;Nature Genetics,2003

4. Discovery and refinement of loci associated with lipid levels;Global Lipids Genetics Consortium;Nature Genetics,2013

5. Efficient design for Mendelian randomization studies: subsample and two-sample instrumental variable estimators;Pierce;American Journal of Epidemiology,2013

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