Precise CCM1 gene correction and inactivation in patient‐derived endothelial cells: Modeling Knudson's two‐hit hypothesis in vitro-Reference-Cited by-同舟云学术

Precise CCM1 gene correction and inactivation in patient‐derived endothelial cells: Modeling Knudson's two‐hit hypothesis in vitro

Published:2019-05-23 Issue:7 Volume:7 Page:
ISSN:2324-9269
Container-title:Molecular Genetics & Genomic Medicine
language:en
Short-container-title:Mol Genet Genomic Med

Author:

Spiegler Stefanie¹^ORCID,Rath Matthias¹,Much Christiane D.¹,Sendtner Barbara S.¹,Felbor Ute¹

Affiliation:

1. Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute of Genetics and Functional Genomics University of Greifswald Greifswald Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Genetics(clinical),Genetics,Molecular Biology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/mgg3.755

Reference41 articles.

1. Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9

2. Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

3. Tissue regeneration using endothelial colony-forming cells: promising cells for vascular repair

4. Mutations within the Programmed Cell Death 10 Gene Cause Cerebral Cavernous Malformations

5. Concise Review: Endothelial Progenitor Cells in Regenerative Medicine: Applications and Challenges

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