Affiliation:
1. Department of Molecular Sciences and Nanosystems Università Ca' Foscari Campus Scientifico Via Torino 155 30174 Venezia-Mestre Italy
2. Pathology Unit Department of Molecular Biology and Translational Research Centro di Riferimento Oncologico di Aviano (CRO) IRCCS via Franco Gallini 2 33081 Aviano Italy
3. Elettra-Sincrotrone Trieste Area Science Park, S.S. 14 Km 163.5, Basovizza 34149 Trieste Italy
4. Dipartimento di Scienze Chimiche Università degli Studi di Padova via Marzolo 1 35131 Padova Italy
Abstract
AbstractA general synthetic entryway into novel cationic Pd(II) indenyl complexes bearing one alkyl/aryl phosphine and oneN‐heterocyclic carbene is reported. All metal complexes have been exhaustively characterized by spectroscopic and structural analyses, highlighting that the indenyl fragment has an hapticity intermediate between η3and η5. Most of the target complexes are stable in solid state and in solution for a long time. Two different applications of these organopalladium compounds are proposed. Firstly, they have been tested as antiproliferative agents towards three different ovarian cancer cell lines, showing a cytotoxicity significantly higher than that of cisplatin, with a clear dependence on the nature of the coordinated phosphine. Moreover, the similar cytotoxicity towards cisplatin‐sensitive and cisplatin‐resistant cell lines suggests that these new palladium derivatives act with a different mechanism of action with respect to classical platinum‐based drugs.Finally, the water‐soluble palladium complexes bearing 1,3,5‐triaza‐7‐phosphaadamantane (PTA) have demonstrated interesting catalytic performances in Suzuki–Miyaura coupling in aqueous media, being, inter alia, readily and efficiently recyclable.
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1 articles.
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