Simultaneous detection of stable isotope-labeled and unlabeledl-tryptophan and of its main metabolites,l-kynurenine, serotonin and quinolinic acid, by gas chromatography/negative ion chemical ionization mass spectrometry

Author:

Sano Mitsue12,Ferchaud-Roucher Véronique3,Nael Charlotte3,Aguesse Audrey3,Poupeau Guillaume1,Castellano Blandine1,Darmaun Dominique1

Affiliation:

1. UMR 1280 Physiologie des Adaptations Nutritionnelles, INRA; Université de Nantes; Nantes France

2. Laboratories of Food Science and Nutrition, School of Human Culture; The University of Shiga Prefecture; Shiga Japan

3. Mass Spectrometry Core Facility; CRNH; Nantes France

Publisher

Wiley

Subject

Spectroscopy

Reference26 articles.

1. Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated l-tryptophan metabolism;Takikawa;Biochem. Biophys. Res. Commun.,2005

2. Comparison of the nicotinamide catabolism among rat strains;Takahashi;Biosci. Biotechnol. Biochem.,2009

3. Changes in the urinary excretion of the metabolites of the tryptophan-niacin pathway during pregnancy in Japanese women and rats;Fukuwatari;J. Nutr. Sci. Vitaminol.,2004

4. Tryptophan-kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later;Oxenkrug;Isr. J. Psychiatry Relat. Sci.,2010

5. Diurnal variations in human urinary excretion of nicotinamide catabolites: effects of stress on the metabolism of nicotinamide;Okamoto;Am. J. Clin. Nutr.,2003

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