Comparative pharmacokinetics studies of benzoylhypaconine, benzoylmesaconine, benzoylaconine and hypaconitine in rats by LC-MS method after administration of Radix Aconiti Lateralis Praeparata extract and Dahuang Fuzi Decoction

Author:

Liu Xiao12,Li Huan123,Song Xiaoqing12,Qin Kunming3,Guo Hui12,Wu Li12,Cai Hao12,Cai Baochang123

Affiliation:

1. College of Pharmacy; Nanjing University of Chinese Medicine; Nanjing 210023 China

2. Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing; Nanjing University of Chinese Medicine; Nanjing 210023 China

3. Nanjing Haichang Chinese Medicine Group Corporation; Nanjing 210061 China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference16 articles.

1. Pharmacodynamic research and clinical application of Dahuang Fuzi Decotion;Liang;Traditional Chinese Patent Medicine,2005

2. Aconitum in traditional Chinese medicine - a valuable drug or an unpredictable risk;Singhuber;Journal of Ethnopharmacology,2009

3. Pharmacokinetics of aconitine as the targeted marker of Fuzi (Aconitum carmichaeli) following single and multiple oral administrations of Fuzi extracts in rat by UPLC/MS/MS;Tang;Journal of Ethnopharmacology,2012

4. LC-MS/MS determination and pharmacokinetic study of albiflorin and paeoniforin in rat plasma after oral administration of Radix paeoniae Alba extract and Tang-Min-Liang-Wan;Tong;Biomedical Chromatography,2010

5. The intestinel cytochrome P450 3A and P-glycoprotein: barriers to drug absorption;Wang;Chinese Pharmacological Bulletin,2003

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