Development of a Translational Model to Assess the Impact of Opioid Overdose and Naloxone Dosing on Respiratory Depression and Cardiac Arrest

Author:

Mann John1,Samieegohar Mohammadreza1,Chaturbedi Anik1,Zirkle Joel1,Han Xiaomei1,Ahmadi S. Farzad1ORCID,Eshleman Amy2,Janowsky Aaron2,Wolfrum Katherine2,Swanson Tracy2,Bloom Shelley2,Dahan Albert3ORCID,Olofsen Erik3,Florian Jeffry1,Strauss David G.1ORCID,Li Zhihua1ORCID

Affiliation:

1. Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research US Food and Drug Administration Silver Spring Maryland USA

2. Department of Veteran's Affairs Portland Health Care System Portland Oregon USA

3. Leiden University Medical Center Leiden The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference51 articles.

1. Centers for Disease Control and Prevention.Drug overdose deaths (2021).

2. National Instititue on Drug Abuse.Overdose death rates (2022).

3. Drug and Opioid-Involved Overdose Deaths — United States, 2013–2017

4. The U.S. Department of Health and Human Services.What is the US opioid epidemic? (2019).

5. Naloxone dosage for opioid reversal: current evidence and clinical implications

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