Comprehensive metabolic study of IOX4 in equine urine and plasma using liquid chromatography/electrospray ionization Q Exactive high‐resolution mass spectrometer for the purpose of doping control-Reference-Cited by-同舟云学术

Comprehensive metabolic study of IOX4 in equine urine and plasma using liquid chromatography/electrospray ionization Q Exactive high‐resolution mass spectrometer for the purpose of doping control

Published:2021-10-21 Issue: Volume: Page:
ISSN:1942-7603
Container-title:Drug Testing and Analysis
language:en
Short-container-title:Drug Test Anal

Author:

Ishii Hideaki¹²^ORCID,Shibuya Mariko¹^ORCID,So Yat‐Ming³^ORCID,Wong Jenny K. Y.³^ORCID,Ho Emmie N. M.³^ORCID,Kusano Kanichi⁴^ORCID,Sone Yu⁴,Kamiya Takahiro⁵,Wakuno Ai⁵,Ito Hideki⁵,Miyata Kenji⁶,Yamada Masayuki¹,Leung Gary Ngai‐Wa¹^ORCID

Affiliation:

1. Drug Analysis Department Laboratory of Racing Chemistry Utsunomiya Tochigi Japan

2. Department of Pharmaceutical Sciences Tohoku University Hospital Sendai Miyagi Japan

3. Racing Laboratory, The Hong Kong Jockey Club Sha Tin Racecourse Sha Tin N.T. Hong Kong

4. Veterinarian Section, Equine Department JRA Minato Tokyo Japan

5. Equine Veterinary Clinic, Horse Racing School Japan Racing Association Shiroi Chiba Japan

6. JRA Equestrian Park Utsunomiya Office Utsunomiya Tochigi Japan

Funder

Japan Racing Association

Publisher

Wiley

Subject

Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/dta.3172

Reference39 articles.

1. WIPO (PCT).WO2003018553A1. Oral antidiabetic agents.https://patentimages.storage.googleapis.com/ae/e2/a1/e5870fb02e4ced/WO2003018553A1.pdf. Accessed September 13 2021.

2. European Patent Office.WO 2008/067871. Substituted dihydropyrazolones for treating cardiovascular and haematological diseases.https://patentimages.storage.googleapis.com/7e/8f/65/89d65078c03796/EP2084151B1.pdf. Accessed September 13 2021.

3. Discovery of molidustat (BAY 85‐3934): a small‐molecule oral HIF‐prolyl hydroxylase (HIF‐PH) inhibitor for the treatment of renal anemia;Beck H;ChemMedChem,2018

4. Structural basis of prolyl hydroxylase domain inhibition by molidustat;Figg WD;ChemMedChem,2021

5. Structure of an HIF‐1alpha‐pVHL complex: hydroxyproline recognition in signaling;Min JH;Science,2002

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pharmacokinetic study of osilodrostat and identification of mono‐hydroxylated metabolite in equine plasma for the purpose of doping control;Rapid Communications in Mass Spectrometry;2024-01-16

2. First evidence of the incorporation of daprodustat and other hypoxia-inducible factor stabilizers into equine hair by passive transfer based on segmental quantitative analysis;Journal of Pharmaceutical and Biomedical Analysis;2023-10

3. Segmental analysis and long-term monitoring of vadadustat in equine hair for the purpose of doping control;Journal of Analytical Toxicology;2023-08-18

4. First Evidence of the Incorporation of Daprodustat and Other Hypoxia-Inducible Factor Stabilizers into Equine Hair by Passive Diffusion Based on Segmental Quantitative Analysis;2023

5. Generic approach for the discovery of drug metabolites in horses based on data-dependent acquisition by liquid chromatography high-resolution mass spectrometry and its applications to pharmacokinetic study of daprodustat;Analytical and Bioanalytical Chemistry;2022-10-01