Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice

Author:

Seubert Bastian1,Grünwald Barbara1,Kobuch Julia1,Cui Haissi1,Schelter Florian1,Schaten Susanne1,Siveke Jens T.2,Lim Ngee H.3,Nagase Hideaki3,Simonavicius Nicole4,Heikenwalder Mathias4,Reinheckel Thomas5,Sleeman Jonathan P.67,Janssen Klaus-Peter8,Knolle Percy A.1,Krüger Achim1

Affiliation:

1. Institut für Experimentelle Onkologie und Therapieforschung; Institute of Molecular Immunology Technische Universität München; München Germany

2. II. Medizinische Klinik; Technische Universität München; München Germany

3. Chirurgische Klinik und Poliklinik des Klinikums rechts der Isar; Technische Universität München; München Germany

4. Technische Universität München/Helmholtz Zentrum München; München Germany

5. Institute of Molecular Medicine and Cell Research and BIOSS Centre for Biological Signalling Studies; Albert-Ludwigs-University Freiburg; Freiburg Germany

6. Centre for Biomedicine and Medical Technology Mannheim; Medical Faculty Mannheim, University Heidelberg; Mannheim Germany

7. KIT Karlsruhe Campus Nord; Institute for Toxicology and Genetics, Eggenstein-Leopoldshafen; Germany

8. Kennedy Institute of Rheumatology Division, Faculty of Medicine; University of Oxford; London UK

Funder

Deutsche Forschungsgemeinschaft

European Commission

National Institute of Arthritis and Musculoskeletal and Skin Diseases

European Research Council

Bundesministerium für Wissenschaft, Forschung und Wirtschaft

Publisher

Wiley

Subject

Hepatology

Reference33 articles.

1. Cancer metastasis: building a framework;Gupta;Cell,2006

2. Matrix metalloproteinases and tumor metastasis;Deryugina;Cancer Metastasis Rev,2006

3. Matrix metalloproteinase inhibitors and cancer: trials and tribulations;Coussens;Science,2002

4. Plasma and serum levels of tissue inhibitor of metalloproteinases-1 are associated with prognosis in node-negative breast cancer: a prospective study;Würtz;Mol Cell Proteomics MCP,2008

5. High preoperative plasma tissue inhibitor of metalloproteinase-1 levels are associated with short survival of patients with colorectal cancer;Holten-Andersen;Clin Cancer Res,2000

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