Clinical Utility of Random Anti–Tumor Necrosis Factor Drug–Level Testing and Measurement of Antidrug Antibodies on the Long‐Term Treatment Response in Rheumatoid Arthritis

Author:

Jani Meghna1,Chinoy Hector2,Warren Richard B.3,Griffiths Christopher E. M.3,Plant Darren4,Fu Bo5,Morgan Ann W.6,Wilson Anthony G.7,Isaacs John D.8,Hyrich KimmeL.9,Barton Anne4,Prouse P. J.,Moitra R. K.,Shawe D. J.,Nisar M.,Fairburn K.,Nixon J.,Barnes T.,Hui M.,Coady D.,Wright D.,Morley C.,Raftery G.,Bracewell C.,Bridges M.,Armstrong D.,Chuck A. J.,Hailwood S.,Kumar N.,Ashok D.,Reece R.,O'Reilly S. C.,Ding T.,Badcock L. J.,Deighton C. M.,Raj N.,Regan M. R.,Summers G. D.,Williams R. A.,Lambert J. R.,Stevens R.,Wilkinson C.,Kelly C. A.,Hamilton J.,Heycock C. R.,Saravanan V.,Cope A.,Garrood T.,Ng N.,Kirkham B.,Green M.,Gough A.,Lawson C.,Das D.,Borbas E.,Wazir T.,Emery P.,Bingham S.,Bird H. A.,Conaghan P.G.,Pease C. T.,Wakefield R. J.,Buch M.,Bruce I.,Gorodkin R.,Ho P.,Parker B.,Smith W.,Jenkins E.,Mukhtyar C.,Gaffney K.,Macgregor A. J.,Marshall T.,Merry P.,DeSilva C.,Birrell F. N.,Crook P. R.,Szebenyi B.,Bates D.,James D.,Gillott T.,Alvi A.,Grey C.,Browning J.,McHale J. F.,Gaywood I.C.,Jones A. C.,Lanyon P.,Pande I.,Doherty M.,Gupta A.,Courtney P. A.,Srikanth A.,Abhishek A.,Das L.,Pattrick M.,Snowden H. N.,Bowden A. P.,Smith E. E.,Klimiuk P.,Speden D. J.,Naz S.,Ledingham J. M.,Hull R. G.,McCrae F.,Cooper A.,Young‐Min S. A.,Wong E.,Shaban R.,Woolf A. D.,Davis M.,Hutchinson D.,Endean A.,Mewar D.,Tunn E. J.,Nelson K.,Kennedy T. D.,Dubois C.,Pauling J.,Korendowych E.,Jenkinson T.,Sengupta R.,Bhalla A.,McHugh N.,O'Neil T.,Herrick A. L.,Jones A. K.,Cooper R. G.,Dixon W. G.,Harrison B.,Buckley C. D.,Carruthers D. C.,Elamanchi R.,Gordon P. C.,Grindulis K. A.,Khattak F.,Raza K.,Situnayake K.,Akil M.,Till S.,Dunkley L.,Tattersall R.,Kilding R.,Tait T.,Maxwell J.,Till S.,Kuet K.-P.,Plant M. J.,Clarke F.,Fordham J. N.,Tuck S.,Pathare S. K.,Paul A.,Marguerie C. P.,Rigby S. P.,Dunn N.,Abbas I.,Filer C.,Abernethy V. E.,Clewes A. R.,Dawson J. K.,Kitas G.,Erb N.,Klocke R.,Whallett A. J.,Douglas K.,Pace A.,Sandhu R.,John H.,Shand L.,Lane S.,Foster H.,Griffiths B.,Griffiths I.,Kay L.,Ng W.-F.,Platt P. N.,Walker D. J.,Peterson P.,Lorenzi A.,Friswell M.,Thompson B.,Lee M.,Pratt A.,Hopkinson N. D.,Dunne C. A.,Quilty B.,Marks J.,Mukherjee S.,Mulherin D.,Chalam S. V.,Price T.,Sheeran T.,Venkatachalam S.,Baskar S.,Al- Allaf W.,McKenna F.,Shah P.,Filer A.,Bowman S. J.,Jobanputra P.,Rankin E. C.,Allen M.,Chaudhuri K.,Dubey S.,Price‐Forbes A.,Ravindran J.,Samanta A.,Sheldon P.,Hassan W.,Francis J.,Kinder A.,Neame R.,Moorthy A.,Bukhari M.,Ottewell L.,Palkonyai E.,Hider S.,Hassell A.,Menon A.,Dowson C.,Kamath S.,Packham J.,Dutta S.,Price S.,Roddy E.,Paskins Z.,O'Reilly D. T.,Rajagopal V.,Bhagat S.,Chattopadhyay C. B.,Green M.,Quinn D.,Isdale A.,Brown A.,Saleem B.,Foo B.,Al Saffar Z.,Koduri G.,

Affiliation:

1. Meghna Jani, MBChB, MSc, MRCP: Centre for Musculoskeletal ResearchInstitute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science CentreManchester UK

2. Hector Chinoy, MBBS, PhD, MRCP, MSc, BMedSci: Centre for Musculoskeletal ResearchInstitute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science CentreManchester UK

3. Richard B. Warren, BSc, MBChB, PhD, MRCP, Christopher E. M. Griffiths, BSc, MBBS, MD, FRCP, FRCPath, FMedSci: The Dermatology CentreSalford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science CentreManchester UK

4. Darren Plant, PhD, Anne Barton, MBChB, PhD, FRCP: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal ResearchInstitute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science CentreManchester UK

5. Bo Fu, PhD: Centre for BiostatisticsInstitute of Population Health, University of Manchester, Manchester Academic Health Science CentreManchester UK

6. University of LeedsLeeds UK

7. University of SheffieldSheffield UK

8. Institute of Cellular Medicine, Newcastle University, and NIHR Newcastle Biomedical Research CentreNewcastle‐upon‐Tyne UK

9. Kimme L. Hyrich, MD, PhD, FRCPC: Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal ResearchUniversity of ManchesterManchester UK

Funder

Medical Research Council Clinical Training Fellow

North West England Medical Research Council Fellowship Scheme in Clinical Pharmacology and Therapeutics

Medical Research Council

ICON

GlaxoSmithKline

AstraZeneca

Medical Evaluation Unit

Arthritis Research UK

NIHR Manchester Musculoskeletal Biomedical Research Unit

NIHR Biomedical Research Unit Funding Scheme

Publisher

Wiley

Subject

Immunology,Rheumatology,Immunology and Allergy

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