In Vivo Microstructure Imaging in Oropharyngeal Squamous Cell Carcinoma Using the Random Walk With Barriers Model

Author:

Cao Yue123ORCID,Davarani Siamak Nejad1,You Daekeun1,Feiweier Thorsten4,Casper Keith5,Balis Ulysses6,Udager Aaron6,Balter James1,Mierzwa Michelle1

Affiliation:

1. Department of Radiation Oncology University of Michigan Ann Arbor Michigan USA

2. Department of Radiology University of Michigan Ann Arbor Michigan USA

3. Department of Biomedical Engineering University of Michigan Ann Arbor Michigan USA

4. Siemens Healthcare GmbH Erlangen Germany

5. Department of Otolaryngology University of Michigan Ann Arbor Michigan USA

6. Department of Pathology University of Michigan Ann Arbor Michigan USA

Abstract

BackgroundApparent diffusion coefficient is not specifically sensitive to tumor microstructure and therapy‐induced cellular changes.PurposeTo investigate time‐dependent diffusion imaging with the short‐time‐limit random walk with barriers model (STL‐RWBM) for quantifying microstructure parameters and early cancer cellular response to therapy.Study TypeProspective.PopulationTwenty‐seven patients (median age of 58 years and 7.4% of females) with p16+/p16− oropharyngeal/oral cavity squamous cell carcinomas (OPSCC/OCSCC) underwent MRI scans before therapy, of which 16 patients had second scans at 2 weeks of the 7‐weeks chemoradiation therapy (CRT).Field Strength/Sequence3‐T, diffusion sequence with oscillating gradient spine echo (OGSE) and pulse gradient spin echo (PGSE).AssessmentDiffusion weighted images were acquired using OGSE and PGSE. Effective diffusion times were derived for the STL‐RWBM to estimate free diffusion coefficient D0, volume‐to‐surface area ratio of cellular membranes V/S, and cell membrane permeability κ. Mean values of these parameters were calculated in tumor volumes.Statistical TestsTumor microstructure parameters were compared with clinical stages of p16+ I‐II OPSCC, p16+ III OPSCC, and p16− IV OCSCC by Spearman's rank correlation and with digital pathological analysis of a resected tissue sample. Tumor microstructure parameter responses during CRT in the 16 patients were assessed by paired t‐tests. A P‐value of <0.05 was considered statistically significant.ResultsThe derived effective diffusion times affected estimated values of V/S and κ by 40%. The tumor V/S values were significantly correlated with clinical stages (r = 0.47) as an increase from low to high clinical stages. The in vivo estimated cell size agreed with one from pathological analysis of a tissue sample. Early tumor cellular responses showed a significant increase in D0 (14%, P = 0.03) and non‐significant increases in κ (56%, P = 0.6) and V/S (10%, P = 0.1).Data ConclusionEffective diffusion time estimation might impact microstructure parameter estimation. The tumor V/S was correlated with OPSCC/OCSCC clinical stages.Level of Evidence1Technical Efficacy Stage1

Publisher

Wiley

Subject

Radiology, Nuclear Medicine and imaging

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3