Daptomycin plus ceftaroline salvage therapy for persistent Staphylococcus epidermidis bacteremia

Author:

Zhang Hayden12ORCID,Tran Kylie3,Lindley Richard456,Dotel Ravindra1

Affiliation:

1. Department of Infectious Diseases Blacktown Hospital Sydney New South Wales Australia

2. Blacktown Mount Druitt Clinical School Western Sydney University Sydney New South Wales Australia

3. Pharmacy Department Blacktown Hospital Sydney New South Wales Australia

4. Department of Geriatrics Blacktown Hospital Sydney New South Wales Australia

5. Westmead Applied Research Centre University of Sydney Sydney New South Wales Australia

6. The George Institute for Global Health Sydney New South Wales Australia

Abstract

Key Clinical MessageInitial antibiotics for true Staphylococcus epidermidis bacteremia include vancomycin or linezolid, but if bacteremia persists, consideration should be made for salvage combination therapy regimes such as daptomycin with ceftaroline.

Publisher

Wiley

Reference11 articles.

1. Staphylococcus epidermidis — the 'accidental' pathogen

2. Commentary: Significance of Staphylococcus epidermidis in Health Care-Associated Infections, from Contaminant to Clinically Relevant Pathogen: This Is a Wake-Up Call!

3. Coagulase-Negative Staphylococci

4. Clinical Characteristics and Outcomes of Persistent Staphylococcal Bacteremia in a Tertiary Care Hospital

5. The European Committee on Antimicrobial Susceptibility Testing.Breakpoint tables for interpretation of MICs and zone diameters. EUCAST.2023. Updated 2023 June 6. Accessed July 30 2023.https://www.eucast.org/clinical_breakpoints

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