Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification

Author:

Lan Zirong1234,Chen An1234,Li Li5,Ye Yuanzhi1234,Liang Qingchun6,Dong Qianqian1234,Wang Siyi1234,Fu Mingwei1234,Li Yining1234,Liu Xiaoyu1234,Zhu Zhenyu1234,Ou Jing‐Song7,Qiu Xiaozhong8910,Lu Lihe11,Yan Jianyun1234ORCID

Affiliation:

1. Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital Southern Medical University Guangzhou PR China

2. Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation Guangzhou PR China

3. Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Guangzhou PR China

4. Sino‐Japanese Cooperation Platform for Translational Research in Heart Failure Guangzhou PR China

5. Department of Cardiology, Guangzhou Red Cross Hospital Jinan University Guangzhou PR China

6. Department of Anesthesiology, The Third Affiliated Hospital Southern Medical University Guangzhou PR China

7. Division of Cardiac Surgery, National‐Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, NHC Key Laboratory of Assisted Circulation, The First Affiliated Hospital Sun Yat‐Sen University Guangzhou PR China

8. The Fifth Affiliated Hospital Southern Medical University Guangzhou PR China

9. Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University Guangzhou PR China

10. School of Basic Medical Sciences Southern Medical University Guangzhou PR China

11. Department of Pathophysiology, Zhongshan Medical School Sun Yat‐Sen University Guangzhou PR China

Funder

China Postdoctoral Science Foundation

Guangdong Basic and Applied Basic Research Foundation

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pathology and Forensic Medicine

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