Affiliation:
1. Department of Engineering for Innovation Medicine University of Verona Verona Italy
2. Neurology Unit Hospital of Trento Trento Italy
3. Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health University of Verona Verona Italy
4. Medical Physics Department Hospital of Trento Trento Italy
5. Neuro‐radiology Unit Hospital of Trento Trento Italy
Abstract
AbstractThe purpose of this study is to demonstrate that T2‐weighted imaging with very long echo time (TE > 300 ms) can provide relevant information in neurodegenerative/inflammatory disorder. Twenty patients affected by relapsing–remitting multiple sclerosis with stable disease course underwent 1.5 T 3D FLAIR, 3D T1‐weighted, and a multi‐echo sequence with 32 echoes (TE = 10–320 ms). Focal lesions (FL) were identified on FLAIR. T1‐images were processed to segment deep gray matter (dGM), white matter (WM), FL sub‐volumes with T1 hypo‐intensity (T1FL), and dGM volumes (atrophy). Clinical‐radiological parameters included Expanded Disability Status Scale (EDSS), disease duration, patient age, T1FL, and dGM atrophy. Correlation analysis was performed between the mean signal intensity (SI) computed on the non‐lesional dGM and WM at different TE versus the clinical‐radiological parameters. Multivariable linear regressions were fitted to the data to assess the association between the dependent variable EDSS and the independent variables obtained by T1FL lesion load and the mean SI of dGM and WM at the different TE. A clear trend is observed, with a systematic strengthening of the significance of the correlation at longer TE for all the relationships with the clinical‐radiological parameters, becoming significant (p < 0.05) for EDSS, T1FL volumes, and dGM atrophy. Multivariable linear regressions show that at shorter TE, the SI of the T2‐weighted sequences is not relevant for describing the EDSS variability while the T1FL volumes are relevant, and vice versa, at very‐long TEs (around 300 ms); the SI of the T2‐weighted sequences significantly (p < 0.05) describes the EDSS variability. By very long TE, the SI primarily originates from water with a T2 longer than 250 ms and/or free water, which may be arising from the perivascular space (PVS). Very‐long T2‐weighting might detect dilated PVS and represent an unexplored MR approach in neurofluid imaging of neurodegenerative/inflammatory diseases.