Affiliation:
1. Outpatient Department Fifth Medical Center of Chinese PLA General Hospital Beijing China
2. Department of Endocrinology and Metabolism Fifth Medical Center of Chinese PLA General Hospital Beijing China
3. Center for Disease Control and Prevention of Xicheng District Beijing China
4. Department of Pathology Fifth Medical Center of Chinese PLA General Hospital Beijing China
Abstract
Key Clinical MessageUltrasound‐guided core needle biopsy combined with immunohistochemistry and molecular testing could improve the diagnostic accuracy of bone metastases from follicular thyroid carcinoma, help to predict distant metastasis and prognosis.AbstractMetastatic thyroid follicular carcinoma presenting initially with bone lesion is uncommon, its prime symptom is gradual onset, localized pain. Patient with bone metastasis who were diagnosed before thyroidectomy had a higher rate of mortality, clinician should be cautious in eliciting the clinical history and this insidious symptom in middle age group, carry out further examination. We are presenting two case reports of a follicular thyroid carcinoma with bone metastasis, ultrasound‐guided core needle biopsy combined with immunohistochemistry (IHC) were carried out by our clinical team to determine the source and nature of the tumor, relevant literature was reviewed, molecular testing was discussed, we believe core needle biopsy combined with IHC and molecular testing improve the diagnostic accuracy of bone metastases from follicular thyroid carcinoma.