Affiliation:
1. Department of Hematology/Hematopoietic Cell Transplantation City of Hope National Medical Center Duarte California USA
2. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston Texas USA
3. Division of Biostatistics City of Hope National Medical Center Duarte California USA
4. Beckman Research Institute City of Hope National Medical Center Duarte California USA
5. Department of Clinical and Translational Project Development City of Hope National Medical Center Duarte California USA
Abstract
AbstractBackgroundThis study evaluated the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of 8‐chloro‐adenosine (8‐Cl‐Ado) in patients with relapsed/refractory acute myeloid leukemia (AML).Methods8‐Cl‐Ado was administered daily for 5 days; the starting dose was 100 mg/m2, the highest dose tested was 800 mg/m2. The end points were toxicity, disease response, and PK/PD measurements.ResultsThe predominant nonhematologic toxicity was cardiac with grade ≥3 toxicity. Plasma PK in all patients suggested heterogeneity among patients, yet, some dose‐dependency for the accumulation of 8‐Cl‐Ado. Two 8‐Cl‐Ado metabolites accumulated at similar levels to 8‐Cl‐Ado. Cellular PK in eight patients indicated accumulation of 8‐Cl‐ATP, which was associated with AML blast cytoreduction in peripheral blood. The authors determined the RP2D of 8‐Cl‐Ado to be 400 mg/m2.ConclusionsGiven the cardiac adverse events observed, patients require monitoring for arrhythmias and QT interval during infusion. Although peripheral blood cytoreduction was observed, responses were transient, suggesting combination strategies will be required.