Burden of late effects in a nationwide sample of long‐term breast cancer survivors

Author:

Smedsland Solveig K.12ORCID,Falk Ragnhild S.3,Reinertsen Kristin V.1,Kiserud Cecilie E.1,Brekke Mette4,Bøhn Synne H.1,Dahl Alv A.1ORCID,Vandraas Kathrine F.1

Affiliation:

1. Department of Oncology National Advisory Unit for Late Effects After Cancer Treatment Oslo University Hospital Oslo Norway

2. Department of Community Medicine and Global Health Institute of Health and Society University of Oslo Oslo Norway

3. Oslo Centre for Biostatistics and Epidemiology Research Support Services Oslo University Hospital Oslo Norway

4. General Practice Research Unit Institute of Health and Society University of Oslo Oslo Norway

Abstract

AbstractBackgroundLong‐term breast cancer survivors (BCSs) may experience several late effects (LEs) simultaneously. This study aimed to identify subgroups of 8‐year BCSs with higher burden of LEs who could benefit from closer survivorship care, explore variables associated with higher symptom burden, and describe how symptom burden may affect general functioning.MethodsAll Norwegian women aged 20 to 65 years when diagnosed with stage I‐III breast cancer in 2011 and 2012 were invited (n = 2803). The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire/BR23, the Fatigue Questionnaire, Assessment of Survivor Concerns, and Scale for Chemotherapy Induced Long‐term Neurotoxicity were used to assess 10 common LEs and general functioning. Using latent class analysis, subgroups of BCSs with similar burden of LEs were identified. Multinominal regression analysis were performed to examine variables associated with higher symptom burden.ResultsThe final sample consisted of 1353 BCSs; 46% had low, 37% medium, and 17% high symptom burden. Younger age, short education, axillary dissection, higher systemic treatment burden, higher body mass index, and physical inactivity were associated with higher symptom burden. General functioning scores were lower, and the proportion on disability pension were higher among BCSs in the two most burdened subgroups compared with those in the low burden subgroup.ConclusionMore than half of long‐term BCSs suffered from medium or high symptom burden and experienced impaired general functioning compared with BCS with low symptom burden. Younger age and systemic treatment were important risk factors for higher symptom burden. BCSs at risk of higher symptom burdens should be identified and offered closer and extended survivorship care.

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference51 articles.

1. Norway CRo.Cancer in Norway 2021;2022. Available from:https://www.kreftregisteret.no/globalassets/cancer‐in‐norway/2021/cin_report.pdf

2. Cancer Statistics, 2021

3. Cancer Survivorship Research: Challenge and Opportunity

4. Late effects of breast cancer treatment and potentials for rehabilitation

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