C1188D mutation abolishes specific recognition between MLL1‐CXXC domain and CpG site by inducing conformational switch of flexible N‐terminal

Author:

Chen Jiawen1ORCID,Qi Yanping12,Duan Yong3,Duan Mojie1ORCID,Yang Minghui14

Affiliation:

1. Key Laboratory of Magnetic Resonance in Biological Systems, National Center for Magnetic Resonances in Wuhan, State Key laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences Wuhan China

2. College of Physical Science and Technology Central China Normal University Wuhan China

3. Department of Biomedical Engineering and UC Davis Genome Center University of California at Davis Davis California USA

4. Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan China

Funder

National Institutes of Health

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

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