Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers

Author:

Stickel Felix1,Lutz Philipp2,Buch Stephan3,Nischalke Hans Dieter2,Silva Ines4,Rausch Vanessa4,Fischer Janett5,Weiss Karl Heinz6,Gotthardt Daniel6,Rosendahl Jonas7,Marot Astrid8,Elamly Mona8,Krawczyk Marcin910,Casper Markus9,Lammert Frank9,Buckley Thomas W. M.11,McQuillin Andrew11,Spengler Ulrich2,Eyer Florian12,Vogel Arndt13,Marhenke Silke13,Felden Johann14,Wege Henning14,Sharma Rohini15,Atkinson Stephen15ORCID,Franke Andre16,Nehring Sophie3,Moser Vincent3,Schafmayer Clemens17,Spahr Laurent18,Lackner Carolin19,Stauber Rudolf E.20ORCID,Canbay Ali21ORCID,Link Alexander21ORCID,Valenti Luca2223ORCID,Grove Jane I.2425,Aithal Guruprasad P.2425,Marquardt Jens U.26ORCID,Fateen Waleed2425,Zopf Steffen27,Dufour Jean‐Francois28,Trebicka Jonel29,Datz Christian30,Deltenre Pierre8ORCID,Mueller Sebastian4,Berg Thomas5,Hampe Jochen3,Morgan Marsha Y.31

Affiliation:

1. Department of Gastroenterology and Hepatology University Hospital of Zürich Switzerland

2. Department of Internal Medicine I University of Bonn Bonn Germany

3. Medical Department 1 University Hospital Dresden TU Dresden Germany

4. Department of Internal Medicine and Center for Alcohol Research Salem Medical Center University Hospital Heidelberg Heidelberg Germany

5. Division of Hepatology, Clinic and Polyclinic for Gastroenterology, Hepatology, Infectiology and Pneumology University Clinic Leipzig Leipzig Germany

6. Department of Internal Medicine IV Medical University of Heidelberg Germany

7. Department of Gastroenterology University Hospital Halle/Saale Germany

8. Division of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois University of Lausanne Switzerland

9. Department of Medicine II Saarland University Medical Center Homburg Germany

10. Laboratory of Metabolic Liver Diseases Department of General, Transplant and Liver Surgery Centre for Preclinical Research Medical University of Warsaw Warsaw Poland

11. Molecular Psychiatry Laboratory Division of Psychiatry University College London UK

12. Department of Clinical Toxicology Klinikum Rechts der Isar Technical University of Munich Germany

13. Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Germany

14. First Department of Medicine University Medical Center Hamburg‐Eppendorf HamburgGermany

15. Department of Metabolism, Digestion & Reproduction Division of Surgery and Cancer Imperial College London London UK

16. Institute of Clinical Molecular Biology Kiel University Kiel Germany

17. Department of Visceral and Thoracic Surgery Kiel University Kiel Germany

18. Departments of Gastroenterology and Hepatology University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland

19. Institute of Pathology Medical University of Graz Austria

20. Division of Gastroenterology and Hepatology Department of Internal Medicine Medical University of Graz Austria

21. Ruhr-Universität Bochum Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH Bochum Germany

22. Department of Pathophysiology and Transplantation Università degli Studi di Milano Milan Italy

23. Translational Medicine – Department of Transfusion Medicine and Hematology Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico Milan Italy

24. NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham Nottingham UK

25. Nottingham Digestive Diseases Centre University of Nottingham Nottingham UK

26. Department of Medicine I Johannes Gutenberg‐Universität Mainz Mainz Germany

27. Medical Department 1 University of Erlangen‐Nuremberg Germany

28. University Clinic for Visceral Surgery and Medicine Inselspital University of Berne Berne Switzerland

29. Department of Internal Medicine I Goethe University Frankfurt Frankfurt Germany

30. Department of Internal Medicine Hospital Oberndorf Teaching Hospital of the Paracelsus Private Medical University of Salzburg Oberndorf Austria

31. UCL Institute for Liver & Digestive Health Division of Medicine Royal Free Campus University College London UK

Funder

Deutsche Krebshilfe

Publisher

Wiley

Subject

Hepatology

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