Affiliation:
1. Department of Neurosurgery, Sanbo Brain Hospital Capital Medical University Beijing China
2. Department of Neurology, Sanbo Brain Hospital Capital Medical University Beijing China
3. Department of Brain Institute, Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Epilepsy Research, Sanbo Brain Hospital Capital Medical University Beijing China
Abstract
AbstractObjectiveApproximately 20%–30% of mesial temporal lobe epilepsy (MTLE) patients got unfavorable seizure control after surgery, and there was a discrepancy about the reasons for the surgical failure. The functional connectivity (FC) patterns obtained from stereo‐electroencephalography (SEEG) reveal information about the dynamics of the epileptic brain and the added value of extracting information that was not identifiable in the SEEG data using FC analysis. This study aims to find out the patterns of the potential epileptogenic network of failure patients and the electrophysiological predictors of reoperation.MethodsFrom January 2012 to December 2019, the MTLE patients with surgical failure were reviewed, and all patients underwent SEEG‐guided reoperation. The epileptogenic network was quantified by calculating FC indicators, including phase slope index (PSI), mutual information (MI) strength, imaginary coherence (icoh), and Granger causality.ResultsTen patients with 13 seizures were included in the analysis, and 7 of them achieved a favorable outcome after the SEEG‐guided reoperation. The surgical zone (SZ) with a favorable prognosis showed greater outward information flow than the non‐SZ, whereas the SZ with an unfavorable prognosis showed greater inward information flow. The recurrent patients with favorable prognosis had strong connectivity between the posterior hippocampus, temporal neocortex, and insula, whereas the patients with unfavorable prognosis showed strong functional connectivity between the insula and temporal–parietal‐occipital junction. The power spectrum of patients with favorable prognosis was significantly lower than that of patients with unfavorable prognosis, especially showing a more oscillation power of low frequency.SignificanceThe SEEG‐guided reoperation could achieve favorable seizure control outcomes for recurrent patients. The FCs were a potential indicator to help construct the temporal epileptic network and predictor for the reoperative prognosis in the recurrent patients.
Funder
National Natural Science Foundation of China
Subject
Neurology (clinical),Neurology
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献