Branched chain α-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice

Author:

Krishnan Bharathi1,Massilamany Chandirasegaran1,Basavalingappa Rakesh H.1,Gangaplara Arunakumar12,Kang Guobin3,Li Qingsheng3,Uzal Francisco A.4,Strande Jennifer L.5,Delhon Gustavo A.1,Riethoven Jean-Jack6,Steffen David1,Reddy Jay1ORCID

Affiliation:

1. School of Veterinary Medicine and Biomedical Sciences; University of Nebraska-Lincoln; Lincoln Nebraska USA

2. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda Maryland USA

3. Nebraska Center for Virology, School of Biological Sciences; University of Nebraska-Lincoln; Lincoln Nebraska USA

4. School of Veterinary Medicine; University of California; Davis California USA

5. Department of Medicine, Cell Biology, Neurobiology and Anatomy; Medical College of Wisconsin; Milwaukee Wisconsin USA

6. Center for Biotechnology; University of Nebraska-Lincoln; Lincoln Nebraska USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference35 articles.

1. Myocarditis and idiopathic dilated cardiomyopathy;Brown;Am. J. Med,1995

2. Identification of an Epitope from adenine nucleotide translocator 1 that induces inflammation in heart in A/J mice;Basavalingappa;Am. J. Pathol,2016

3. Epitope mapping of the branched chain alpha-ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD-E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy;Ansari;J. Immunol,1994

4. Cardiac autoantibodies to myosin and other heart-specific autoantigens in myocarditis and dilated cardiomyopathy;Caforio;Autoimmunity,2001

5. Humoral immune response against contractile proteins (actin and myosin) during cardiovascular disease;De Scheerder;Eur. Heart J,1991

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