mAb806 binding to epidermal growth factor receptor: a computational study

Author:

Ng Yao Zong1,Kannan Srinivasaraghavan1,Lane David P.2,Fuentes Gloria1,Verma Chandra S.134

Affiliation:

1. Bioinformatics Institute, Agency for Science; Technology and Research (A*STAR), Matrix; Singapore 138671 Singapore

2. p53 Laboratory, Agency for Science; Technology and Research (A*STAR), Neuros/Immunos; Singapore 138648 Singapore

3. Department of Biological Sciences; National University of Singapore; Singapore 117543 Singapore

4. School of Biological Sciences; Nanyang Technological University; Singapore 637551 Singapore

Funder

A*STAR, SIngapore

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Reference62 articles.

1. EGF-ERBB signalling: towards the systems level;Citri;Nat Rev Mol Cell Biol,2006

2. The complexity of targeting EGFR signalling in cancer: from expression to turnover;Sebastian;Biochim Biophys Acta,2006

3. Structure-based view of epidermal growth factor receptor regulation;Ferguson;Annu Rev Biophys,2008

4. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization;Ferguson;Mol Cell,2003

5. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor;Schlessinger;Cell,2002

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