1. Roche Pharmaceutical Research and Early Development; Large Molecule Research, Roche Innovation Center Penzberg; Penzberg 82377 Germany
2. Department of Statistics; Oxford University; Oxford OX1 3TG United Kingdom
3. Roche Pharmaceutical Research and Early Development; Informatics, Roche Innovation Center Penzberg; Penzberg 82377 Germany
4. Fachgebiet Protein Modelling; Technische Universität München; Freising 85354 Germany