Prediction of VH-VL domain orientation for antibody variable domain modeling

Author:

Bujotzek Alexander1,Dunbar James2,Lipsmeier Florian3,Schäfer Wolfgang1,Antes Iris4,Deane Charlotte M.2,Georges Guy1

Affiliation:

1. Roche Pharmaceutical Research and Early Development; Large Molecule Research, Roche Innovation Center Penzberg; Penzberg 82377 Germany

2. Department of Statistics; Oxford University; Oxford OX1 3TG United Kingdom

3. Roche Pharmaceutical Research and Early Development; Informatics, Roche Innovation Center Penzberg; Penzberg 82377 Germany

4. Fachgebiet Protein Modelling; Technische Universität München; Freising 85354 Germany

Funder

Roche

Engineering and Physical Sciences Research Council

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Reference30 articles.

1. Computer-aided antibody design;Kuroda;Protein Eng Des Sel,2012

2. Antibody modeling assessment;Almagro;Proteins,2011

3. Antibody modeling assessment II: structures and models;Teplyakov;Proteins,2014

4. SAbDab: the structural antibody database;Dunbar;Nucleic Acids Res,2014

5. Conformations of immunoglobulin hypervariable regions;Chothia;Nature,1989

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