Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter-Reference-Cited by-同舟云学术

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Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter

Published:2016-12-09 Issue:2 Volume:6 Page:110-119
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Emoto C¹²,Fukuda T¹²,Johnson TN³,Neuhoff S³,Sadhasivam S⁴,Vinks AA¹²

Affiliation:

1. Division of Clinical PharmacologyCincinnati Children's Hospital Medical CenterCincinnati Ohio USA

2. Department of Pediatrics, College of MedicineUniversity of CincinnatiCincinnati Ohio USA

3. Simcyp Limited (a Certara company)St. Louis Missouri USA

4. Department of AnesthesiaCincinnati Children's Hospital Medical CenterCincinnati Ohio USA

Funder

Center for Clinical & Translational Science & Training

National Center for Advancing Translational Sciences of the National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12144

Reference41 articles.

1. Mechanistic Basis of Using Body Size and Maturation to Predict Clearance in Humans

2. Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children

3. Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development

4. Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide

5. Morphine Pharmacokinetics and Metabolism in Humans

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1. The role of drug efflux and uptake transporters in the plasma pharmacokinetics and tissue disposition of morphine and its main metabolites;Toxicology and Applied Pharmacology;2024-09

2. PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans;Acta Pharmacologica Sinica;2024-04-03

3. Salivary therapeutic monitoring of methadone toxicity in neonates after transplacental transfer from parturient mothers treated with oral methadone guided by PBPK modeling;Computational Toxicology;2024-03

4. Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD);Pharmaceutical Research;2024-02-13

5. Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans;Current Drug Metabolism;2023-12

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