Preoperative urine neutrophil gelatinase‐associated lipocalin predicts mortality in colorectal cancer patients after laparoscopic surgery: A single‐center study

Author:

Huynh Thanh Long12,Dao Bui Quy Quyen3,Nguyen Manh Khiem1,Nguyen Huu Dung4,Nguyen Trung Kien56,Le Viet Thang56ORCID

Affiliation:

1. Nguyen Tri Phuong Hospital Ho Chi Minh Vietnam

2. Nguyen Tat Thanh University Ho Chi Minh Vietnam

3. Cho Ray Hospital Ho Chi Minh Vietnam

4. Bach Mai Hospital Ha Noi Vietnam

5. Military Hospital 103 Ha Noi Vietnam

6. Vietnam Military Medical University Ha Noi Vietnam

Abstract

AbstractPurposeTo determine the rate of acute kidney injury (AKI) after laparoscopic colorectal cancer (CRC) surgery and the predictive value of urine neutrophil gelatinase‐associated lipocalin (uNGAL) for postoperative AKI and mortality during 3 years of follow‐up.MethodsA total of 216 CRC patients who had undergone laparoscopic surgery were included in our study. We divided all patients into two groups, including group 1 (n = 31) with postoperative AKI and group 2 (n = 185) without postoperative AKI. Urine NGAL was measured using the ELISA technique. Clinical and laboratory data were collected the day before surgery. Postoperative AKI included events occurring within 7 days of the index operation, and mortality was obtained during 3 years of follow‐up.ResultsThe ratio of postoperative AKI was 14.35% (31/216 patients). The urine NGAL level in group 1 was significantly higher than in group 2, p < 0.001. At cut‐off value = 14.94 ng/mL, uNGAL has a predictive value for AKI (area under the curve [AUC] = 0.858, p < 0.001). After 3 years of follow‐up, the total mortality rate was 7.9%. The mortality rate in group 1 (45.2%) was significantly higher than in group 2 (1.6%) with p < 0.001). At cut‐off value = 19.85 ng/mL, uNGAL has a predictive value for mortality (AUC = 0.941, p < 0.001).ConclusionsThe rate of acute kidney injury after laparoscopic CRC surgery was 14.35%. Preoperative urine NGAL has a good predictive value for postoperative acute kidney injury and mortality during 3 years of follow‐up.

Publisher

Wiley

Subject

General Medicine

Reference43 articles.

1. Colorectal cancer

2. Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor‐initiating cells;Testa U;Med Sci,2018

3. Colorectal cancer statistics, 2020

4. Global patterns and trends in colorectal cancer incidence and mortality

5. Colorectal carcinoma: pathologic aspects;Fleming M;J Gastrointest Oncol,2012

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