Effect of protein cryoconcentration and processing conditions on kinetics of dimer formation for a monoclonal antibody: A case study on bioprocessing
Author:
Affiliation:
1. Drug Product Development and Operations, Biologics CMCTeva Biopharmaceuticals West Chester Pennsylvania
Publisher
Wiley
Subject
Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.2836
Reference26 articles.
1. The therapeutic monoclonal antibody market
2. Aggregates in monoclonal antibody manufacturing processes
3. Evolving trends in mAb production processes
4. Current Perspectives on Stability of Protein Drug Products during Formulation, Fill and Finish Operations
5. Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization
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3. Scaling Down Large-Scale Thawing of Monoclonal Antibody Solutions: 3D Temperature Profiles, Changes in Concentration, and Density Gradients;Pharmaceutical Research;2021-11
4. Interfacial Stress and Container Failure During Freezing of Bulk Protein Solutions Can Be Prevented by Local Heating;AAPS PharmSciTech;2020-09-01
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