Real-time assessment of13C metabolism reveals an early lactate increase in the brain of rats with acute liver failure

Author:

Chavarria Laia123,Romero-Giménez Jordi1,Monteagudo Eva4,Lope-Piedrafita Silvia45,Cordoba Juan123

Affiliation:

1. Liver Unit; Hospital Vall Hebron; Barcelona Spain

2. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD); Instituto de Salud Carlos III; Madrid Spain

3. Departament de Medicina; Universitat Autònoma de Barcelona; Cerdanyola del Vallès Spain

4. Servei de Ressonància Magnètica Nuclear; Universitat Autònoma de Barcelona; Cerdanyola del Vallès Spain

5. Centro de Investigación Biomédica en Red en Bioingeniería; Biomateriales y Nanomedicina (CIBER-BBN); Cerdanyola del Vallès Spain

Funder

Instituto de Salud Carlos III co-financed by the European Regional Development Fund (ERDF)

Publisher

Wiley

Subject

Spectroscopy,Radiology, Nuclear Medicine and imaging,Molecular Medicine

Reference41 articles.

1. Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema;Cordoba;Hepatology,1996

2. Pathogenetic mechanisms of hepatic encephalopathy;Haussinger;Gut,2008

3. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis;Ott;Neurochem. Int.,2005

4. In vivo 31P NMR spectroscopy of energy rich phosphates in the brain of the hyperammonemic rat;Friolet;Biochem. Biophys. Res. Commun.,1989

5. Activity-dependent regulation of energy metabolism by astrocytes: an update;Pellerin;Glia,2007

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