The ADNI PET Core at 20

Author:

Jagust William J.1,Koeppe Robert A.2,Rabinovici Gil D.3,Villemagne Victor L.4,Harrison Theresa M.1,Landau Susan M.1,

Affiliation:

1. Department of Neuroscience University of California Berkeley California USA

2. Department of Radiology University of Michigan Ann Arbor Michigan USA

3. Department of Neurology University of California San Francisco California USA

4. Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA

Abstract

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) PET Core has evolved over time, beginning with positron emission tomography (PET) imaging of a subsample of participants with [18F]fluorodeoxyglucose (FDG)‐PET, adding tracers for measurement of β‐amyloid, followed by tau tracers. This review examines the evolution of the ADNI PET Core, the novel aspects of PET imaging in each stage of ADNI, and gives an accounting of PET images available in the ADNI database. The ADNI PET Core has been and continues to be a rich resource that provides quantitative PET data and preprocessed PET images to the scientific community, allowing interrogation of both basic and clinically relevant questions. By standardizing methods across different PET scanners and multiple PET tracers, the Core has demonstrated the feasibility of large‐scale, multi‐center PET studies. Data managed and disseminated by the PET Core has been critical to defining pathophysiological models of Alzheimer's disease (AD) and helped to drive methods used in modern therapeutic trials.Highlights The ADNI PET Core began with FDG‐PET and now includes three amyloid and three tau PET ligands. The PET Core has standardized acquisition and analysis of multitracer PET images. The ADNI PET Core helped to develop methods that have facilitated clinical trials in AD.

Funder

National Institute on Aging

Publisher

Wiley

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