Direct Immunoactivation by Chemotherapeutic Drugs in Cancer Treatment

Author:

Wang Yurui1,Song Yiran2,He Yazhi2,Wang Yang2,Maurer Jochen3,Kiessling Fabian4,Lammers Twan4,Wang Feng5,Shi Yang1ORCID

Affiliation:

1. Department of Polymer Therapeutics Institute for Experimental Molecular Imaging Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering Faculty of Medicine RWTH Aachen University 52074 Aachen Germany

2. Department of Gastroenterology Shanghai 10th People's Hospital School of Medicine Tongji University Shanghai 200072 P. R. China

3. Department of Gynecology and Obstetrics Uniklinik RWTH Aachen 52074 Aachen Germany

4. Institute for Experimental Molecular Imaging Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering Faculty of Medicine RWTH Aachen University 52074 Aachen Germany

5. Department of Gastroenterology, Huadong Hospital, Shanghai Medical College Fudan University Shanghai 200040 P. R. China

Abstract

AbstractThe immune system plays a crucial role in recognizing and eliminating pathogenic substances and malignant cells in the body. For cancer treatment, immunotherapy is becoming the standard treatment for many types of cancer and is often combined with chemotherapy. Although chemotherapeutic agents are often reported to have adverse effects, including immunosuppression, they can also play a positive role in immunotherapy by directly stimulating the immune system. This has been demonstrated in preclinical and clinical studies in the past decades. Chemotherapeutics can activate immune cells through different immune receptors and signaling pathways, depending on their chemical structure and formulation. In this review, the direct immunoactivation effects of chemotherapeutics and the possible mechanisms behind these effects are summarized and discussed. Finally, chemo‐immunotherapeutic combinations are prospected for the more effective and safer treatment of cancer.

Funder

Bundesministerium für Bildung und Forschung

China Scholarship Council

HORIZON EUROPE European Research Council

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Pharmacology (medical),Biochemistry (medical),Genetics (clinical),Pharmaceutical Science,Pharmacology,Medicine (miscellaneous)

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