Recent Progress of Paclitaxel Delivery Systems: Covalent and Noncovalent Approaches

Author:

Wang Jiaoyang1,Li Xueqiao2,Wu Wenna2,Xu Xin‐Ming2,Xu Hui1,Zhang Tao2ORCID

Affiliation:

1. School of Pharmacy Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University) Ministry of Education Yantai University Yantai 264005 China

2. Department of Applied Chemistry, School of Chemistry and Chemical Engineering Yantai University Yantai 264005 China

Abstract

AbstractPaclitaxel (PTX) is a broad‐spectrum alkaloid anticancer drug with high therapeutic efficacy. However, PTX has a very low water solubility and its metabolism demonstrates nonlinear pharmacokinetic characteristics, resulting in systemic adverse reactions in clinical applications. Many endeavors are devoted to develop new PTX preparations in response to these obstacles, and some are used in clinical phase of cancer treatment. In particular, highly specific medical intervention at nanoscale is an emerging research field focusing on nanoapproaches to solve clinical problems. In a perspective of nanomedicine, the recent covalent and noncovalent approaches toward PTX formulation on various substrates, as well as their advantages and disadvantages during preclinical researches and clinical applications are herein summarized. It is anticipated that nanotechnology‐based drug delivery systems can further enhance therapeutic efficiencies of PTX, by reducing systemic side effects and alleviating severely negative effects on patients.

Funder

Natural Science Foundation of Shandong Province

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology (medical),Biochemistry (medical),Genetics (clinical),Pharmaceutical Science,Pharmacology,Medicine (miscellaneous)

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