Capitalization of Graphene/Chitosan Nanocomposites as Intriguing Vehicles for Targeted Anti‐Cancer Drug Delivery

Abstract

AbstractThe effective combination of various polysaccharides with graphene derivatives toward the formation of nanocomposites has gained enormous interest for a number of emerging biological and biomedical applications. The intriguing properties of the individual materials are further improved upon the realization of (nano)composites, thus providing new insights and property enhancement in terms of durability, flexibility, biocompatibility, low‐toxicity, and antibacterial/antimicrobial behavior. Therefore, novel (nano)composite agents are prepared and investigated to serve as ideal carriers or scaffold materials in regenerative medicine, biosensing, disease diagnosis and treatment, drug delivery, as well as stem cell and tissue engineering applications. This topical review summarizes the most recent studies published during the last quinquennium (2018–2022), on the development of anticancer drug delivery systems (DDSs) based on graphene/chitosan (CS) nanocomposites. The followed synthetic routes and the integrated properties of the composite materials are analyzed, discussing the impact of their utilization in the field of drug delivery for the treatment of various cancer types. The prospects and future research trends in the field are also discussed.