Multidisciplinary Approaches in the Treatment of Retinal Degenerative Diseases: A Review

Author:

Chen Jianqi1,Zhuo Xiaohua2,Zhu Yingting1,Zhuo Yehong1ORCID

Affiliation:

1. State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Sun Yatsen University Guangzhou 510060 China

2. Guangdong Provincial Clinical Research Center for Eye Disease, Shenzhen Clinical Research Center for Eye Disease Shenzhen Eye Hospital Jinan University Shenzhen 518040 China

Abstract

AbstractRetinal degenerative diseases (RDDs) cause irreversible blindness and affect ≈285 million individuals worldwide. The unavailability of treatment to stop the progression of RDDs or restore normal visual function necessitated development of novel therapeutic strategies. In recent years, multidisciplinary approaches have shown great potential for the treatment of RDDs, including intraocular delivery systems, retinal scaffolds for cell therapy, and visual prostheses with different stimulation strategies. This review focuses on the development prospects and shortcomings of various multidisciplinary treatment approaches for RDDs. The results of this review will hopefully inspire further innovation in the design of novel multidisciplinary approaches for RDD treatment and accelerate their commercialization.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology (medical),Biochemistry (medical),Genetics (clinical),Pharmaceutical Science,Pharmacology,Medicine (miscellaneous)

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