PEGylation of Recombinant Human Deoxyribonuclease I Provides a Long‐Acting Version of the Mucolytic for Patients with Cystic Fibrosis

Author:

Guichard Marie‐Julie1,Wilms Tobias1,Mahri Sohaib1,Patil Harshad P.1,Hoton Delphine2,Ucakar Bernard1,Vanvarenberg Kevin1,Cheou Pamela3,Beka Mathilde4,Marbaix Etienne56,Leal Teresinha4,Vanbever Rita1ORCID

Affiliation:

1. Université Catholique de Louvain (UCLouvain) Louvain Drug Research Institute (LDRI), Advanced Drug Delivery and Biomaterials 1200 Brussels Belgium

2. St‐Luc University Hospital Anatomopathology Department 1200 Brussels Belgium

3. UCLouvain, de Duve Institute Experimental Medicine Unit 1200 Brussels Belgium

4. UCLouvain, Institute of Experimental and Clinical Research (IREC) Louvain Center for Toxicology and Applied Pharmacology 1200 Brussels Belgium

5. Department of Communicable Diseases Interactive Research School for Health Affairs Bharati Vidyapeeth University Pune Maharashtra India

6. UCLouvain, de Duve Institute Cell Biology Unit 1200 Brussels Belgium

Publisher

Wiley

Subject

Pharmacology (medical),Biochemistry (medical),Genetics (clinical),Pharmaceutical Science,Pharmacology,Medicine (miscellaneous)

Reference43 articles.

1. Cystic Fibrosis Mutation Database http://www.genet.sickkids.on.ca/. (accessed: October 2020).

2. Post-translational modifications of CFTR: insight into protein trafficking and cystic fibrosis disease

3. CFTR, bicarbonate, and the pathophysiology of cystic fibrosis

4. Cystic Fibrosis Foundation 2019.Patient Registry Annual Data Report.

5. Determinants of adherence in adults with cystic fibrosis

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