Critical roles of long noncoding RNA H19 in cancer-Reference-Cited by-同舟云学术

Critical roles of long noncoding RNA H19 in cancer

Published:2024-04 Issue:3 Volume:42 Page:
ISSN:0263-6484
Container-title:Cell Biochemistry and Function
language:en
Short-container-title:Cell Biochemistry & Function

Author:

Darmadi Darmadi¹,Chugaeva Uliana Y.²,Saleh Raed Obaid³,Hjazi Ahmed⁴,Saleem Hiba Muwafaq⁵^ORCID,Ghildiyal Pallavi⁶,Alwaily Enas R.⁷,Alawadi Ahmed⁸⁹¹⁰,Alnajar Mohammed Jawad¹¹,Ihsan Ali¹²

Affiliation:

1. Department of Internal Medicine, Faculty of Medicine Universitas Sumatera Utara Medan North Sumatera Indonesia

2. Department of Pediatric, Preventive Dentistry and Orthodontics, Institute of Dentistry I.M. Sechenov First Moscow State Medical University (Sechenov University) Moscow Russia

3. Department of Medical Laboratory Techniques Al‐Maarif University College Al‐Anbar Iraq

4. Department of Medical Laboratory, College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Al‐Kharj Saudi Arabia

5. Department of Biology, College of Science University of Anbar Ramadi Iraq

6. Uttaranchal Institute of Pharmaceutical Sciences Uttaranchal University Dehradun India

7. Microbiology Research Group, College of Pharmacy Al‐Ayen University Thi‐Qar Iraq

8. College of Technical Engineering The Islamic University Najaf Iraq

9. College of Technical Engineering The Islamic University of Al Diwaniyah Al Diwaniyah Iraq

10. College of Technical Engineering The Islamic University of Babylon Hillah Iraq

11. Anesthesia Techniques Al‐Nisour University College Baghdad Iraq

12. College of Technical Engineering Imam Ja'afar Al‐Sadiq University Al‐Muthanna Iraq

Abstract

AbstractLong noncoding RNAs (lncRNAs) are a category of noncoding RNAs characterized by their length, often exceeding 200 nucleotides. There is a growing body of data that indicate the significant involvement of lncRNAs in a wide range of disorders, including cancer. lncRNA H19 was among the initial lncRNAs to be identified and is transcribed from the H19 gene. The H19 lncRNA exhibits significant upregulation in a diverse range of human malignancies, such as breast, colorectal, pancreatic, glioma, and gastric cancer. Moreover, the overexpression of H19 is frequently associated with a worse prognosis among individuals diagnosed with cancer. H19 has been shown to have a role in facilitating several cellular processes, including cell proliferation, invasion, migration, epithelial–mesenchymal transition, metastasis, and apoptosis. This article summarizes the aberrant upregulation of H19 in human malignancies, indicating promising avenues for future investigations on cancer diagnostics and therapeutic interventions.

Publisher

Wiley

Reference112 articles.

1. Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention

2. Targeted cancer therapy

3. Non-coding RNA

4. The product of the H19 gene may function as an RNA.

5. History, Discovery, and Classification of lncRNAs