Tacrolimus Elimination in Four Patients With aCYP3A5*3/*3 CYP3A4*22/*22Genotype Combination

Author:

Scheibner Aileen1ORCID,Remmel Rory2,Schladt David3,Oetting William S.4,Guan Weihua5,Wu Baolin5,Dorr Casey6,Israni Ajay367,Jacobson Pamala A.8

Affiliation:

1. University of Minnesota College of Pharmacy; Minneapolis Minnesota

2. Department of Medicinal Chemistry; University of Minnesota College of Pharmacy; Minneapolis Minnesota

3. Minneapolis Medical Research Foundation; Minneapolis Minnesota

4. Department of Experimental and Clinical Pharmacology; University of Minnesota; Minneapolis Minnesota

5. Division of Biostatistics; University of Minnesota; Minneapolis Minnesota

6. Division of Nephrology; Department of Medicine; Hennepin Country Medical Center; Minneapolis Minnesota

7. Epidemiology and Community Health; University of Minnesota School of Public Health; Minneapolis Minnesota

8. Department of Experimental and Clinical Pharmacology; University of Minnesota College of Pharmacy; Minneapolis Minnesota

Publisher

Wiley

Subject

Pharmacology (medical)

Reference27 articles.

1. The disposition of 14C-labeled tacrolimus after intravenous and oral administration in healthy human subjects;Möller;Drug Metab Dispos,1999

2. In vivo CYP3A4 activity, CYP3A5 genotype, and hematocrit predict tacrolimus dose requirements and clearance in renal transplant patients;de Jonge;Clin Pharmacol Ther,2012

3. Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation;Staatz;Clin Pharmacokinet,2004

4. Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone;Iwasaki;Drug Metab Dispos,1993

5. Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro;Dai;Drug Metab Dispos,2006

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