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A nonparametric method to detect increased frequencies of adverse drug reactions over time

  • Published:2018-01-10 Issue:9 Volume:37 Page:1491-1514
  • ISSN:0277-6715
  • Container-title:Statistics in Medicine
  • language:en
  • Short-container-title:Statistics in Medicine

Author:

Heimann Günter1ORCID,Belleli Rossella2,Kerman Jouni3,Fisch Roland3,Kahn Joseph4,Behr Sigrid2,Berlin Conny2

Affiliation:

1. Pharmacometrics; Novartis Pharma AG; Basel Switzerland

2. Quantitative Safety Sciences and Epidemiology; Novartis Pharma AG; Basel Switzerland

3. Statistical Methodology and Consulting Center; Novartis Pharma AG; Basel Switzerland

4. Pharmacometrics; Novartis Pharma; East Hanover NJ USA

Publisher

Wiley

Subject

Statistics and Probability,Epidemiology

Reference11 articles.

1. A data mining approach for signal detection and analysis;Bate;Drug Safety,2002

2. Bayesian data mining in large frequency tables, with an application to the fda spontaneous reporting system;DuMouchel;The Am Statistician,2012

3. A likelihood ratio test based method for signal detection with application to fda's drug safety data;Huang;J Am Stat Assoc,2011

4. Bayesian hierarchical modeling for detecting safety signals in clinical trials;Schuemie;J Biopharm Stat,2011

5. A likelihood ratio based test for longitudinal drug safety data;Huang;Stat Med,2014

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