Efficient recall of SARS‐CoV‐2 variant‐reactive B cells and T responses in the elderly upon heterologous mRNA vaccines as boosters

Author:

Rouers Angeline1ORCID,Wong Nathan1,Goh Yun Shan1,Torres‐Ruesta Anthony1,Tay Matthew Zirui1,Chang Zi Wei1,Fong Siew‐Wai1,Neo Vanessa1,Kam Isaac Kai Jie1,Yeo Nicholas Kim‐Wah1,Huang Yuling1,Loh Chiew Yee1,Hor Pei Xiang1,Wong Joel Xu En1,Tan Yong Jie1,Macary Paul A.2,Qian Xinlei3,Bei Wang4,Ngoh Eve Zi Xian4,Salleh Siti Nazihah Mohd4,Wang Cheng-I4,Poh Xuan Ying5,Rao Suma56,Chia Po Ying567,Ong Sean W. X.56,Lee Tau Hong56,Lin Ray J. H.56,Lim Clarissa5,Teo Jefanie5,Ren Ee Chee4,Lye David Chien5678,Young Barnaby E.567,Ng Lisa F. P.1910,Renia Laurent178,

Affiliation:

1. A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR) Singapore Singapore

2. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore

3. Life Sciences Institute National University of Singapore Singapore Singapore

4. A*STAR Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) Singapore Singapore

5. National Centre for Infectious Diseases Singapore

6. Department of Infectious Diseases Tan Tock Seng Hospital Singapore

7. Lee Kong Chian School of Medicine Nanyang Technological University Singapore

8. School of Biological Sciences Nanyang Technological University Singapore

9. National Institute of Health Research, Health Protection Research Unit in Emerging and Zoonotic Infections University of Liverpool Liverpool UK

10. Institute of Infection, Veterinary and Ecological Sciences University of Liverpool Liverpool UK

Funder

U.S. Food and Drug Administration

Agency for Science, Technology and Research

Publisher

Wiley

Subject

Infectious Diseases,Virology

Reference33 articles.

1. RitchieH MathieuE Rodés‐GuiraoL et al. Coronavirus (COVID‐19) vaccinations [Internet]. Accessed July 1  2020. https://ourworldindata.org/covid-vaccinations

2. Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

3. Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months

4. 11 vaccines granted emergency use listing (EUL) by WHO [Internet]. Accessed July 1 2022.  https://covid19.trackvaccines.org/agency/who/

5. USFDA.Coronavirus (COVID‐19) update: FDA expands eligibility for COVID‐19 vaccine boosters. US Food and Drug Administration. 2021.https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-expands-eligibility-covid-19-vaccine-boosters

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