Affiliation:
1. Department of Orthopaedic Surgery The First Affiliated Hospital, Fujian Medical University Fuzhou 350005 P. R. China
2. Spine Center Department of Orthopaedics Changzheng Hospital Naval Medical University (Second Military Medical University) Shanghai 200003 P. R. China
3. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China
4. Department of Orthopaedics Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai 200080 P. R. China
Abstract
AbstractSkin wounds accompanied by bacterial infections threaten human health, and conventional antibiotic treatments are ineffective for drug‐resistant bacterial infections and chronically infected wounds. The development of non‐antibiotic‐dependent therapeutics is highly desired but remains a challenging issue. Recently, 2D silicene nanosheets with considerable biocompatibility, biodegradability, and photothermal‐conversion performance have received increasing attention in biomedical fields. Herein, copper‐containing nanoparticles‐loaded silicene (Cu2.8O@silicene‐BSA) nanosheets with triple enzyme mimicry catalytic (peroxidase, catalase, and oxidase‐like) activities and photothermal function are rationally designed and fabricated for efficient bacterial elimination, angiogenesis promotion, and accelerated wound healing. Cu2.8O@silicene‐BSA nanosheets display excellent antibacterial activity through synergistic effects of reactive oxygen species generated from multiple catalytic reactions, intrinsic bactericidal activity of released Cu2+ ions, and photothermal effects, achieving high antibacterial efficiencies on methicillin‐resistant Staphylococcus aureus (MRSA) of 99.1 ± 0.7% in vitro and 97.2 ± 1.6% in vivo. In addition, Cu2.8O@silicene‐BSA nanosheets exhibit high biocompatibility for promoting human umbilical vein endothelial cell (HUVEC) proliferation and angiogenic differentiation. In vivo experiments reveal that Cu2.8O@silicene‐BSA nanosheets with synergistic photothermal/chemodynamic therapeutics effectively accelerate MRSA‐infected wound healing by eliminating bacteria, alleviating inflammation, boosting collagen deposition, and promoting angiogenesis. This research presents a promising strategy to engineer photothermal‐assisted nanozyme catalysis for bacteria‐invaded wound healing.
Funder
National Natural Science Foundation of China
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
1 articles.
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