Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Author:

Zhuang Ze‐Ming1ORCID,Wang Yong1,Feng Zi‐Xuan1,Lin Xiao‐Ying1,Wang Zheng‐Cai1,Zhong Xin‐Cao1,Guo Kai1,Zhong Yu‐Fan1,Fang Qing‐Qing1,Wu Xiao‐Jin2,Chen Jian2,Tan Wei‐Qiang1ORCID

Affiliation:

1. Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine 3 East Qingchun Road Hangzhou 310016 P. R. China

2. Department of Ultrasound in Medicine The Fourth Affiliated Hospital Zhejiang University School of Medicine Yiwu 322000 P. R. China

Abstract

AbstractWounds and the subsequent formation of scars constitute a unified and complex phased process. Effective treatment is crucial; however, the diverse therapeutic approaches for different wounds and scars, as well as varying treatment needs at different stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), as a novel minimally invasive transdermal drug delivery system, has the potential for integrated and programmed treatment of various diseases and has shown promising applications in different types of wounds and scars. In this comprehensive review, the latest applications and biotechnological innovations of MNPs in these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, and manage related symptoms. Moreover, potential applications in various scenarios are discussed. Additionally, the side effects, manufacturing processes, and material selection to explore the clinical translational potential are investigated. This groundwork can provide a theoretical basis and serve as a catalyst for future innovations in the pursuit of favorable therapeutic options for skin tissue regeneration.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

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