Aurozyme: A Revolutionary Nanozyme in Colitis, Switching Peroxidase‐Like to Catalase‐Like Activity

Author:

Kim Hyung Shik1ORCID,Lee Sieun1,Lee Dong Yun1234ORCID

Affiliation:

1. Department of Bioengineering College of Engineering, and BK FOUR Biopharmaceutical Innovation Leader for Education and Research Group Hanyang University Seoul 04763 Republic of Korea

2. Institute of Nano Science and Technology (INST) Hanyang University Seoul 04763 Republic of Korea

3. Institute for Bioengineering and Biopharmaceutical Research (IBBR) Hanyang University Seoul 04763 Republic of Korea

4. Elixir Pharmatech Inc. Seoul 07463 Republic of Korea

Abstract

AbstractA therapeutic strategy that could address colitis of multiple etiologies while restoring the dysbiosis of gut microbiota is attractive. Here, Aurozyme, a novel nanomedicine comprised of gold nanoparticles (AuNPs) and glycyrrhizin (GL) with a glycol chitosan coating layer, as a promising approach for colitis, is demonstrated. The unique feature of Aurozyme is the conversion of harmful peroxidase‐like activity of AuNPs to beneficial catalase‐like activity due to the amine‐rich environment provided by the glycol chitosan. This conversion process enables Aurozyme to oxidize the hydroxyl radicals derived from AuNP, producing water and oxygen molecules. In fact, Aurozyme effectively scavenges reactive oxygen/reactive nitrogen species (ROS/RNS) and damage‐associated molecular patterns (DAMPs), which can attenuate the M1 polarization of macrophage. It exhibits prolonged adhesion to the lesion site, promoting sustained anti‐inflammatory effects and restoring intestinal function in colitis‐challenged mice. Additionally, it increases the abundance and diversity of beneficial probiotics, which are essential for maintaining microbial homeostasis in the gut. The work highlights the transformative potential of nanozymes for the comprehensive treatment of inflammatory disease and represents an innovative switching technology of enzyme‐like activity by Aurozyme.

Funder

National Research Foundation of Korea

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3