Affiliation:
1. International Joint Research Laboratory of Nano‐Micro Architecture Chemistry College of Chemistry Jilin University 2699 Qianjin Street Changchun 130012 P. R. China
2. Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass College of Chemistry and Materials Engineering Zhejiang A&F University Hangzhou 311300 P. R. China
Abstract
AbstractDiscrete organometallic complexes with defined structures are proceeding rapidly in combating malignant tumors due to their multipronged treatment modalities. Many innovative superiorities, such as high antitumor activity, extremely low systemic toxicity, active targeting ability, and enhanced cellular uptake, make them more competent for clinical applications than individual precursors. In particular, coordination‐induced regulation of luminescence and photophysical properties of organic light‐emitting ligands has demonstrated significant potential in the timely evaluation of therapeutic efficacy by bioimaging and enabled synergistic photodynamic therapy (PDT) or photothermal therapy (PTT). This review highlights instructive examples of multimodal radiochemotherapy platforms for cancer ablation based on self‐assembled metallacycles/metallacages, which would be classified by functions in a progressive manner. Finally, the essential demands and some plausible prospects in this field for cancer therapy are also presented.
Funder
Fundamental Research Funds for the Central Universities
Natural Science Foundation of Jilin Province
National Natural Science Foundation of China
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
7 articles.
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