Affiliation:
1. Department of Chemical Engineering Tsinghua University Beijing 100084 China
2. Key Laboratory of Industrial Biocatalysis Ministry of Education Tsinghua University Beijing 100084 China
3. State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China
4. Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China
Abstract
AbstractDue to the outbreak of novel coronavirus pneumonia, messenger RNA (mRNA) technology has attracted heated attention. A specific, safe, and efficient mRNA delivery system is needed. Lipid nanocarriers have become attractive carriers for mRNA delivery due to their high delivery efficiency, few side effects, and easy modification to change their structures and functions. To achieve the desired biological effect, lipid nanocarriers must reach the designated location for effective drug delivery. Therefore, the effects of the composition of lipid nanocarriers on their key properties are briefly reviewed. In addition, the progress of smart drug delivery by changing the composition of lipid nanocarriers is summarized, and the importance of component design and structure is emphasized. Subsequently, this review summarizes the latest progress in lipid nanocarrier‐based mRNA technology and provides corresponding strategies for its current challenges, putting forward valuable information for the future design of lipid nanocarriers and mRNA.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China